The age-Dependent Relationship ranging from Blood pressure and you will Cognitive Handicap: A combination-Sectional Research for the a rural Section of Xi’an, China

The age-Dependent Relationship ranging from Blood pressure and you will Cognitive Handicap: A combination-Sectional Research for the a rural Section of Xi’an, China

Blood circulation pressure is a convertible exposure grounds to have cognitive disability, whilst the matchmaking between hypertension and you can intellectual disability is not totally understood. The intention of this study was to have a look at the end result regarding age for the relationships between blood pressure and you may cognitive impairment.


Blood circulation pressure and you can worldwide intellectual function recommendations are collected out of 1799 members (ages 40–85) which stayed in a town about suburbs out-of Xi’an, China, during from inside the-person interviews. Cognitive handicap is actually defined as a small-Mental state Test (MMSE) get below this new cutoff worth. The effect of age on matchmaking ranging from blood pressure level details [systolic blood circulation pressure (SBP), diastolic hypertension (DBP), mean arterial blood pressure level (MABP), and you may hypertension (HBP, SBP?140 mm Hg and you will/otherwise DBP?90 mm Hg)] and you will cognitive impairment is reviewed from the logistic regression activities using communication and you may stratified study. Blood pressure and you will years were considered to be each other carried on and you can categorical research.


A total of 231 participants were diagnosed as having cognitive impairment based on our criteria. Interaction analysis for the total population showed that SBP (when regarded as continuous data) was positively correlated with cognitive impairment (OR = 1.130 [95% CI, 1.028–1.242] per 10mmHg, P = 0.011); however, the age by SBP interaction term was negatively correlated with cognitive impairment (OR = 0.989 [95% CI, 0.982–0.997] per 10mmHg?year, P = 0.006), indicating that the relationship between SBP and cognitive impairment was age-dependent (OR = 1.130?0.989 (age-55.5) per 10mmHg,40 ?age?85). When the blood pressure and age were considered as binary data, the results were similar to those obtained when they were considered as continuous variables. Stratified multivariate analysis revealed that the relationship between SBP (when regarded as continuous data) and cognitive impairment was positive for patients aged 40–49 years (OR = 1.349 [95% CI: 1.039–1.753] per 10mmHg, P = 0.025) and 50–59 years (OR = 1.185 [95% CI: 1.028–1.366] per 10mmHg, P = 0.019), whereas it tended to be negative for patients aged 60–69 years (OR = 0.878 [95% CI: 0.729–1.058] per 10mmHg, P = 0.171) and ?70 years (OR = 0.927 [95% CI: 0.772–1.113] per 10mmHg, P = 0.416). Results similar to those for SBP were obtained for DBP, MABP and HBP as well. Subsequently, SBP, DBP and MABP were transformed into categorical data (SBP<140mmHg, 140mmHg?SBP<160mmHg, and SBP?160mmHg; DBP<90mmHg, 90mmHg?DBP<100mmHg, and DBP?100mmHg; MABP<100mmHg, 100mmHg?MABP<110mmHg, and MABP?110mmHg), and the stratified multivariate analysis was repeated. This analysis showed that the age-dependent association continued to exist and was especially prominent in the SBP?160 mmHg, DBP?90 mmHg and MABP?110 mmHg groups.


High blood pressure try certainly correlated having cognitive impairment from the middle-old, but this confident connection declines which have increasing decades. Such overall performance showed that certain hypertension administration techniques for various age range are crucial for maintaining intellectual energies.

Citation: Shang S, Li P, Deng M, Jiang Y, Chen C, Qu Q (2016) This-Depending Dating anywhere between Blood circulation pressure and you may Intellectual Handicap: A cross-Sectional Data into the an outlying Area of Xi’an, China. PLoS One to 11(7): e0159485.

Copyright: © 2016 Shang mais aussi al. This is certainly an unbarred supply blog post marketed underneath the regards to the fresh Imaginative Commons Attribution Permit, and therefore it allows unrestricted explore, shipments, and you will breeding in almost any average, offered the original creator and origin try credited.

Data Accessibility: On account of limitations imposed from the government of your Man’s Republic from China, data can’t be made in public found in reference to the new Tort Liability Rules and you will Analytics Laws. Analysis availability has also been restricted of the moral acceptance to guard private information out of people. Anyone in search of accessing the data need to discover ethical approval off medical Integrity Committee of your Earliest Affiliated Healthcare out of Xi’an Jiaotong University (). Requests for a beneficial de-identified analysis set using this investigation can be delivered to relevant copywriter Qiumin Qu () immediately after finding ethical recognition.


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